SnapShot: Histone Modifications

SnapShot: Histone Modifications

H2B H3N-PEPAKSA...PKKGSKKAVTKAQKKD...RKRSRKE SYS...YKVLK ...TGISSK...S...SEASRLAHYNKRSTITSRE...VRL ...AKH...GTKAVTKYTSAK-COO10 20 29 30 42 52 64 75 80 90 98 107 114 120 100 Ar Ph Ph Ac Ar Ph OH Ph Ph Ph Ph Me OH Me Ph Ph Ph Me Me Ph Ph Ac Me/Ac/Bu/Cr Hib/Su/Fo Ac Bu Cr Me Ac Bu Cr Hib Me Ac Bu Cr Ac Bu Cr Me/Ac/Bu Cr/Hib/Ub Me Ac Bu Cr Hib Ac Hib Me/Cr/Hib Su/ Ub / Fo Ph Og Me Ac Hib Su Fo Me/A...

SnapShot: p53 Posttranslational Modifications

P ho sp ho ry la ti o n N-Terminal: S6, S9, S15, T18, S20 ATM, DNAPK, • CK1 ERKs, ATR, p38 • kinase, mTOR, Chk1/Chk2, JNK, MAPKAP2, Hipk4 Activated by DNA damage, UV light, ionizing radiation, replicative senes• cence, or phosphatidylcholines. N-terminal phosphorylation causes p53 stabilization by inhibiting the p53• MDM2 interaction. Knockin mice carrying separate analogs to human Ser18/ • Ser...

P-98: Effect of Mouse Embryo Vitrification on Histone Modifications

Background: Vitrification has been usually used as an assisted reproductive technology in animals and humans. This method needs high concentrations of cryoprotectants that can be toxic with high cooling degrees. Then, vitrification could be change histone modifications such as methylation and acetylation can performance as regulatory controls of gene transcription. So, the purpose of the presen...

SnapShot: Histone Readers

SnapShot: Histone-Modifying Enzymes